BDBM205377 US9249151, 23::US9249151, 25

SMILES CNC(C)C(=O)Nc1cc(cc(NC(=O)c2ccc(Cl)cn2)n1)-c1ccnc2cc(F)cc(F)c12

InChI Key InChIKey=NHQKASIVXKUPSG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 205377   

TargetE3 ubiquitin-protein ligase XIAP [241-356](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM205377(US9249151, 23 | US9249151, 25)
Affinity DataIC50: 120nMT: 2°CAssay Description:R3 domains of human XIAP (covering amino acids 241 to 356; XIAP BIR3) and cIAPl (covering amino acids 256 to 363; cIAPl BIR3) were expressed and puri...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase XIAP [241-356](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM205377(US9249151, 23 | US9249151, 25)
Affinity DataIC50: 1.09E+3nMT: 2°CAssay Description:R3 domains of human XIAP (covering amino acids 241 to 356; XIAP BIR3) and cIAPl (covering amino acids 256 to 363; cIAPl BIR3) were expressed and puri...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBaculoviral IAP repeat-containing protein 3 [256-363](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM205377(US9249151, 23 | US9249151, 25)
Affinity DataIC50: 8nMT: 2°CAssay Description:R3 domains of human XIAP (covering amino acids 241 to 356; XIAP BIR3) and cIAPl (covering amino acids 256 to 363; cIAPl BIR3) were expressed and puri...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBaculoviral IAP repeat-containing protein 3 [256-363](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM205377(US9249151, 23 | US9249151, 25)
Affinity DataIC50: 47nMT: 2°CAssay Description:R3 domains of human XIAP (covering amino acids 241 to 356; XIAP BIR3) and cIAPl (covering amino acids 256 to 363; cIAPl BIR3) were expressed and puri...More data for this Ligand-Target Pair
In DepthDetails
US Patent