BDBM204627 1-(5-butoxy-2-chloro-phenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline::US11419874, Example 6::US9540379, 41

SMILES CCCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccccc3n12

InChI Key InChIKey=ITEIGISUTJIFPA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 204627   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM204627(US9540379, 41 | 1-(5-butoxy-2-chloro-phenyl)-4-met...)
Affinity DataIC50: 1.00E+3nMAssay Description:The DNA of PDE10A1 (AB 020593, 2340 bp) was synthesized and cloned into the vector pCR4. TOPO (Entelechon GmbH, Regensburg, Germany). The gene was th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM204627(US9540379, 41 | 1-(5-butoxy-2-chloro-phenyl)-4-met...)
Affinity DataIC50: 3nMAssay Description:The DNA encoding PDE2A (NM002599) was cloned and the gene was inserted in the baculovirus and the enzyme-protein expressed in SF21-cells. The enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM204627(US9540379, 41 | 1-(5-butoxy-2-chloro-phenyl)-4-met...)
Affinity DataIC50: 3nMAssay Description:Isolated cardiomyocytes were washed twice in PBS at room temperature, transferred to 4% paraformaldehyde (PFA) and gently shaken for 30 min, then was...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM204627(US9540379, 41 | 1-(5-butoxy-2-chloro-phenyl)-4-met...)
Affinity DataIC50: 1.00E+3nMAssay Description:Isolated cardiomyocytes were washed twice in PBS at room temperature, transferred to 4% paraformaldehyde (PFA) and gently shaken for 30 min, then was...More data for this Ligand-Target Pair
In DepthDetails
US Patent