BDBM203874 Mcl-1 inhibitor 10

SMILES Cc1c(c(COc2ccccc2)nn1C)-c1cccc2c(CCCOc3cccc4ccccc34)c([nH]c12)C(O)=O

InChI Key InChIKey=BAQCJHZNIFESNU-UHFFFAOYSA-N

Data  1 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 203874   

LigandPNGBDBM203874(Mcl-1 inhibitor 10)
Affinity DataIC50: 383nMAssay Description:Inhibition of FAM labelled Bid-BH3 binding to N-terminal GST-tagged human recombinant MCL1 expressed in Escherichia coli BL2(DE3) after 60 mins by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM203874(Mcl-1 inhibitor 10)
Affinity DataIC50: 383nMAssay Description:Inhibition of MCL-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM203874(Mcl-1 inhibitor 10)
Affinity DataEC50: >1.10E+4nMAssay Description:Inhibition of MCL-1 in human MOLP8 cells assessed as increase in caspase 3/7 activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Human)
Oncology Innovative Medicines Unit

LigandPNGBDBM203874(Mcl-1 inhibitor 10)
Affinity DataKi:  104nM ΔG°:  -9.49kcal/mole IC50: 383nMpH: 7.4 T: 2°CAssay Description:Compound IC50 values were assessed following a 10-point, half-log10 dilution schema starting at 10 uM compound concentration. The assay was performed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed