BDBM203872 7-(3-((3-Acetylphenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid, 8::Mcl-1 inhibitor 8
SMILES CC(=O)c1cccc(OCc2nn(C)c(C)c2-c2cccc3c(CCCOc4cccc5ccccc45)c([nH]c23)C(O)=O)c1
InChI Key InChIKey=GEDJUAKXFJRZSG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 203872
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan Provinc
Curated by ChEMBL
Hunan Provinc
Curated by ChEMBL
Affinity DataIC50: 237nMAssay Description:Inhibition of FAM labelled Bid-BH3 binding to N-terminal GST-tagged human recombinant MCL1 expressed in Escherichia coli BL2(DE3) after 60 mins by TR...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan Provinc
Curated by ChEMBL
Hunan Provinc
Curated by ChEMBL
Affinity DataIC50: 237nMAssay Description:Inhibition of MCL-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan Provinc
Curated by ChEMBL
Hunan Provinc
Curated by ChEMBL
Affinity DataEC50: 2.70E+3nMAssay Description:Inhibition of MCL-1 in human MOLP8 cells assessed as increase in caspase 3/7 activationMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Human)
Oncology Innovative Medicines Unit
Oncology Innovative Medicines Unit
Affinity DataKi: 64nM ΔG°: -9.77kcal/mole IC50: 237nMpH: 7.4 T: 2°CAssay Description:Compound IC50 values were assessed following a 10-point, half-log10 dilution schema starting at 10 uM compound concentration. The assay was performed...More data for this Ligand-Target Pair