BDBM203868 (S)-N2-benzhydryl-N1-(1-methyl-1H-indol-3-yl)pyrrolidine-1,2-dicarboxamide (5)

SMILES Cn1cc(NC(=O)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c2ccccc12

InChI Key InChIKey=XDHKCZQEUNKJHG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 203868   

TargetComplement factor D [24-253](Human)
Novartis Pharma

LigandPNGBDBM203868((S)-N2-benzhydryl-N1-(1-methyl-1H-indol-3-yl)pyrro...)
Affinity DataIC50: 5.80E+3nMpH: 7.5 T: 2°CAssay Description:Briefly, recombinant human or murine FD catalytic domain (10 nM concentration) were incubated with compound at various concentrations for 1 h at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2016
Entry Details Article
PubMed
TargetComplement factor B [470-764](Human)
Novartis Pharma

LigandPNGBDBM203868((S)-N2-benzhydryl-N1-(1-methyl-1H-indol-3-yl)pyrro...)
Affinity DataIC50: 1.00E+5nMpH: 7.4 T: 2°CAssay Description:Human CVF-Bb complex (3 nM concentration) was incubated with compound at various concentrations for 1 h at room temperature in PBS at pH 7.4, contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2016
Entry Details Article
PubMed
TargetKallikrein-7 [37-253,Y180R](Human)
Novartis Pharma

LigandPNGBDBM203868((S)-N2-benzhydryl-N1-(1-methyl-1H-indol-3-yl)pyrro...)
Affinity DataIC50: 1.00E+5nMpH: 5.6 T: 2°CAssay Description:Recombinant human KLK7 (5 nM concentration) was pre-incubated with inhibitor at various concentrations for 1 h at room temperature in 50 mM sodium ci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2016
Entry Details Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM203868((S)-N2-benzhydryl-N1-(1-methyl-1H-indol-3-yl)pyrro...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of recombinant human complement factor D catalytic domain using Z-Lys-thiobenzylester as substrate preincubated for 1 hr followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetComplement factor D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM203868((S)-N2-benzhydryl-N1-(1-methyl-1H-indol-3-yl)pyrro...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of recombinant human CFD catalytic domain (G24 to A253 residues) expressed in Escherichia coli (Rosetta) using Z-Lys-thiobenzyl and 2,4-di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed