BDBM202380 US10081606, Compound I-12::US9238629, I-12::US9765038, Compound I-12

SMILES COc1ccccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1

InChI Key InChIKey=DSRXZMGDJDQWJM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 202380   

TargetEpidermal growth factor receptor(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM202380(US9238629, I-12 | US10081606, Compound I-12 | US97...)
Affinity DataIC50: 650nMpH: 7.5 T: 2°CAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM202380(US9238629, I-12 | US10081606, Compound I-12 | US97...)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM202380(US9238629, I-12 | US10081606, Compound I-12 | US97...)
Affinity DataIC50: 650nMpH: 7.5Assay Description:The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM202380(US9238629, I-12 | US10081606, Compound I-12 | US97...)
Affinity DataIC50: 1nMpH: 7.5Assay Description:The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM202380(US9238629, I-12 | US10081606, Compound I-12 | US97...)
Affinity DataIC50: 650nMAssay Description:The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202380(US9238629, I-12 | US10081606, Compound I-12 | US97...)
In DepthDetails
US Patent