BDBM200723 US9233086, 10L

SMILES CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccc(F)cc1)c1ccc(F)cc1

InChI Key InChIKey=RZKSQRIPRKWVBU-UHFFFAOYSA-N

Data  2 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 200723   

TargetWD repeat-containing protein 5 [24-334](Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 3.00E+3nMpH: 6.5 T: 2°CAssay Description:All the FP based experiments were performed in MICROFLUOR 2 Black, "U" Bottom, 96-well Microtiter Plates (ThermoSci.) and FP was measured as mP units...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 400nMAssay Description:Inhibition of His-SUMO-fused MLL1 (3762 to 3969 residues) interaction with His-SUMO-fused ASH2L/RBBP5/WDR5 (23 to 334 residues) (unknown origin) expr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 900nMAssay Description:Inhibition of recombinant MLL1 (unknown origin) interaction with recombinant ASH2L/RBBP5/WDR5 (unknown origin) assessed as decrease in histone methyl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetWD repeat-containing protein 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of C-terminal 5-FAM-WIN peptide binding to N-terminal His-tagged WDR5 (24 to 334 residues) (unknown origin) expressed in Rosetta2-(DE3) pL...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 400nMAssay Description:Inhibition of recombinant SUMO-fused MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) expressed in Escherichia coli ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 750nMAssay Description:Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetWD repeat-containing protein 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of fluorescence-labeled Ac-ARA peptide binding to WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetWD repeat-containing protein 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of 10mer-Thr-FAM probe binding to human WDR5 after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetWD repeat-containing protein 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 2.40nMAssay Description:Displacement of fluorescence-labelled Ac-ARA peptide from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetWD repeat-containing protein 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetWD repeat-containing protein 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 2.40nMAssay Description:Binding affinity to WDR5 (unknown origin) fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataKi: <1nMAssay Description:Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetWD repeat-containing protein 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataKi: <1nMAssay Description:Displacement of 5-FAM labelled tracer from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed