BDBM200722 US9233086, 10K

SMILES CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccc(Cl)cc1)c1ccc(Cl)cc1

InChI Key InChIKey=PTJOIPPVAWDZSV-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 200722   

TargetWD repeat-containing protein 5 [24-334](Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM200722(US9233086, 10K)
Affinity DataIC50: 3.00E+3nMpH: 6.5 T: 2°CAssay Description:All the FP based experiments were performed in MICROFLUOR 2 Black, "U" Bottom, 96-well Microtiter Plates (ThermoSci.) and FP was measured as mP units...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM200722(US9233086, 10K)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetWD repeat-containing protein 5(Human)
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandPNGBDBM200722(US9233086, 10K)
Affinity DataIC50: 4.5nMAssay Description:Displacement of fluorescence-labelled Ac-ARA peptide from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM200722(US9233086, 10K)
Affinity DataKi: <1nMAssay Description:Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetWD repeat-containing protein 5(Human)
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandPNGBDBM200722(US9233086, 10K)
Affinity DataKi: <1nMAssay Description:Displacement of 5-FAM labelled tracer from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed