BDBM200439 US10011599, Example 68::US9227969, 68::US9629836, 68

SMILES Cc1nc2cnc3cc(F)c(cc3c2n1[C@H]1CCN(C[C@@H]1F)C(=O)CO)-c1ccc(Oc2nccc(C)n2)cc1Cl

InChI Key InChIKey=NDABNJSZKPTQLB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 200439   

LigandPNGBDBM200439(US9227969, 68 | US9629836, 68 | US10011599, Exampl...)
Affinity DataIC50: 4.70nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
Go to US Patent

LigandPNGBDBM200439(US9227969, 68 | US9629836, 68 | US10011599, Exampl...)
Affinity DataIC50: 4.70nMAssay Description:The radioactive filter binding assay is standardized using recombinant human activated BRAF (V599E) kinase (Cat No. 14-557) and kinase dead MEK1 (K97...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2019
Entry Details
Go to US Patent

LigandPNGBDBM200439(US9227969, 68 | US9629836, 68 | US10011599, Exampl...)
Affinity DataIC50: 4.70nMAssay Description:[MEK1 1mM ATP IC50 uM] A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM200439(US9227969, 68 | US9629836, 68 | US10011599, Exampl...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed