BDBM200372 US10011599, Example 1A::US9227969, 1A::US9629836, 1A

SMILES Cc1nc2cnc3cc(F)c(cc3c2n1[C@H]1CCN(C[C@@H]1F)C(=O)CO)-c1ccc(Oc2ncccn2)cc1Cl

InChI Key InChIKey=WZZBNLYBHUDSHF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 200372   

LigandPNGBDBM200372(US9227969, 1A | US9629836, 1A | US10011599, Exampl...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM200372(US9227969, 1A | US9629836, 1A | US10011599, Exampl...)
Affinity DataIC50: 5nMAssay Description:The radioactive filter binding assay is standardized using recombinant human activated BRAF (V599E) kinase (Cat No. 14-557) and kinase dead MEK1 (K97...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM200372(US9227969, 1A | US9629836, 1A | US10011599, Exampl...)
Affinity DataIC50: 5nMAssay Description:[MEK1 1mM ATP IC50 uM] A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An en...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 3A4(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM200372(US9227969, 1A | US9629836, 1A | US10011599, Exampl...)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM200372(US9227969, 1A | US9629836, 1A | US10011599, Exampl...)
Affinity DataIC50: 25nMAssay Description:Inhibition of wild-type human partial length TRKA (G475 to G790 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed