BDBM199985 US9227959, Reference Compound 1, Ex. 35

SMILES CC1(C)CN(CCO1)C(=O)c1ccc(cn1)C#Cc1cccc(F)c1

InChI Key InChIKey=UBZYCCRHIRZFEK-UHFFFAOYSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 199985   

TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM199985(US9227959, Reference Compound 1, Ex. 35)
Affinity DataEC50:  46nMT: 2°CAssay Description:A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM199985(US9227959, Reference Compound 1, Ex. 35)
Affinity DataKi:  201nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...More data for this Ligand-Target Pair
In DepthDetails
US Patent