BDBM199340 US9221831, 4
SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1)[C@H]1Cc4ccc(F)c5O[C@@H]2[C@]3(CCN1C)c45
InChI Key InChIKey=LURXKAVKEBVYHH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 199340
Affinity DataEC50: 2.92E+3nMpH: 7.4 T: 2°CAssay Description:Functional [35S]GTPgammaS binding assays were conducted as follows. ORL-1 membrane solution was prepared by sequentially adding final concentrations ...More data for this Ligand-Target Pair
Affinity DataEC50: 8.03nMpH: 7.4 T: 2°CAssay Description:[35S]GTPgammaS functional assays were conducted using freshly thawed u-receptor membranes (Perkin Elmer, Shelton, Conn.). Assay reactions were prepar...More data for this Ligand-Target Pair
Affinity DataEC50: 22.8nMpH: 7.4 T: 2°CAssay Description:Functional [35S]GTPgammaS binding assays were conducted as follows. kippa opioid receptor membrane solution was prepared by sequentially adding final...More data for this Ligand-Target Pair
Affinity DataEC50: 67.8nMpH: 7.4 T: 2°CAssay Description:Functional [35S]GTPgammaS binding assays were conducted as follows. Delta opioid receptor membrane solution was prepared by sequentially adding final...More data for this Ligand-Target Pair
Affinity DataKi: 0.190nMpH: 7.4Assay Description:Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recomb...More data for this Ligand-Target Pair
Affinity DataKi: 4.41nM ΔG°: -12.3kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for t-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane...More data for this Ligand-Target Pair
Affinity DataKi: 92.5nM ΔG°: -9.59kcal/molepH: 7.4 T: 2°CAssay Description:Delta-opioid Receptor Binding Assay Procedures were conducted as follows. Radioligand dose-displacement assays used 0.3 nM [3H]-Naltrindole (Perkin E...More data for this Ligand-Target Pair
Affinity DataKi: 286nM ΔG°: -9.67kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (Perkin Elmer, Shelton, Conn.; 87.7 Ci/mmole) with 12 ug mem...More data for this Ligand-Target Pair