BDBM199186 N-(3,4-Dimethoxybenzyl)-1,2,3,4-tetrahydroacridin-9-amine (8e)

SMILES COc1ccc(CNc2c3CCCCc3nc3ccccc23)cc1OC

InChI Key InChIKey=FRMYHFABGOUZJS-UHFFFAOYSA-N

Data  4 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 199186   

TargetCholinesterase(Human)
University of Waterloo

LigandPNGBDBM199186(N-(3,4-Dimethoxybenzyl)-1,2,3,4-tetrahydroacridin-...)
Affinity DataIC50: 20nMpH: 8.0 T: 2°CAssay Description:Test compounds were prepared in DMSO (maximum concentration used 1% v/v), and 10 μL of each (0.001-25 μm final concentration range) was inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Waterloo

LigandPNGBDBM199186(N-(3,4-Dimethoxybenzyl)-1,2,3,4-tetrahydroacridin-...)
Affinity DataIC50: 2.20E+3nMpH: 8.0 T: 2°CAssay Description:Test compounds were prepared in DMSO (maximum concentration used 1% v/v), and 10 μL of each (0.001-25 μm final concentration range) was inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Waterloo

LigandPNGBDBM199186(N-(3,4-Dimethoxybenzyl)-1,2,3,4-tetrahydroacridin-...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate pretreated for 5 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Waterloo

LigandPNGBDBM199186(N-(3,4-Dimethoxybenzyl)-1,2,3,4-tetrahydroacridin-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human BuChE using S-butyrylthiocholine iodide as substrate pretreated for 5 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM199186(N-(3,4-Dimethoxybenzyl)-1,2,3,4-tetrahydroacridin-...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in insect cells using EOMCC as substrate pretreated for 10 mins followed by substrate addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM199186(N-(3,4-Dimethoxybenzyl)-1,2,3,4-tetrahydroacridin-...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in insect cells using DBOMF as substrate pretreated for 10 mins followed by substrate addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Universidad De Sevilla

Curated by ChEMBL
LigandPNGBDBM199186(N-(3,4-Dimethoxybenzyl)-1,2,3,4-tetrahydroacridin-...)
Affinity DataKi:  6.40nMAssay Description:Inhibition of equine serum BuChE assessed as dissociation constant for enzyme-substrate-inhibitor complex using butyrylthiocholine iodide as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Universidad De Sevilla

Curated by ChEMBL
LigandPNGBDBM199186(N-(3,4-Dimethoxybenzyl)-1,2,3,4-tetrahydroacridin-...)
Affinity DataKi:  31nMAssay Description:Inhibition of equine serum BuChE assessed as dissociation constant for enzyme-inhibitor complex using butyrylthiocholine iodide as substrate measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Universidad De Sevilla

Curated by ChEMBL
LigandPNGBDBM199186(N-(3,4-Dimethoxybenzyl)-1,2,3,4-tetrahydroacridin-...)
Affinity DataKi:  210nMAssay Description:Inhibition of electric eel AChE assessed as dissociation constant for enzyme-substrate-inhibitor complex using acetylthiocholine iodide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Universidad De Sevilla

Curated by ChEMBL
LigandPNGBDBM199186(N-(3,4-Dimethoxybenzyl)-1,2,3,4-tetrahydroacridin-...)
Affinity DataKi:  640nMAssay Description:Inhibition of electric eel AChE assessed as dissociation constant for enzyme-inhibitor complex using acetylthiocholine iodide as substrate measured f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed