BDBM19893 (2R)-N-(cyanomethyl)-2-(3-{4-[4-(2-hydroxy-2-methylpropyl)piperazin-1-yl]phenyl}phenyl)-4-methylpentanamide::Nonpeptidic Biaryl Nitrile Compound, 13

SMILES CC(C)C[C@@H](C(=O)NCC#N)c1cccc(c1)-c1ccc(cc1)N1CCN(CC(C)(C)O)CC1

InChI Key InChIKey=NTKXMIPSJBNQQD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 19893   

TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19893((2R)-N-(cyanomethyl)-2-(3-{4-[4-(2-hydroxy-2-methy...)
Affinity DataIC50: 6nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19893((2R)-N-(cyanomethyl)-2-(3-{4-[4-(2-hydroxy-2-methy...)
Affinity DataIC50: 9.55E+3nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19893((2R)-N-(cyanomethyl)-2-(3-{4-[4-(2-hydroxy-2-methy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19893((2R)-N-(cyanomethyl)-2-(3-{4-[4-(2-hydroxy-2-methy...)
Affinity DataIC50: 6.37E+3nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed