BDBM19876 (2R)-N-(Cyanomethyl)-4-methyl-2-[4 -(4-pyridinyl)[1,1 -biphenyl]-3-yl]pentamide::(2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(pyridin-4-yl)phenyl]phenyl}pentanamide::Nonpeptidic Biaryl Nitrile Compound, 40

SMILES CC(C)C[C@@H](C(=O)NCC#N)c1cccc(c1)-c1ccc(cc1)-c1ccncc1

InChI Key InChIKey=BWSKELGOZUEVLA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 19876   

TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19876((2R)-N-(Cyanomethyl)-4-methyl-2-[4 -(4-pyridinyl)[...)
Affinity DataIC50: 97nMpH: 5.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19876((2R)-N-(Cyanomethyl)-4-methyl-2-[4 -(4-pyridinyl)[...)
Affinity DataIC50: 8.39E+3nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19876((2R)-N-(Cyanomethyl)-4-methyl-2-[4 -(4-pyridinyl)[...)
Affinity DataIC50: 1.37E+3nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19876((2R)-N-(Cyanomethyl)-4-methyl-2-[4 -(4-pyridinyl)[...)
Affinity DataIC50: 3.33E+3nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed