BDBM19856 (2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1-yl)phenyl]phenyl}pentanamide::CHEMBL184514::JMC463709 (R)-2::piperazine-containing compound, 11
SMILES CC(C)C[C@@H](C(=O)NCC#N)c1cccc(c1)-c1ccc(cc1)N1CCNCC1
InChI Key InChIKey=AQPCFTUFFUSBNZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 19856
Affinity DataIC50: 2.60E+3nM EC50: 320nMpH: 5.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
Affinity DataIC50: 3.73E+3nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
Affinity DataIC50: 3.95E+3nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibitory concentration against humanized rabbit cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibitory concentration against human cathepsin SMore data for this Ligand-Target Pair
Affinity DataIC50: 3.73E+3nMAssay Description:Inhibitory concentration against human cathepsin LMore data for this Ligand-Target Pair
Affinity DataIC50: 3.95E+3nMAssay Description:Inhibitory concentration against human cathepsin BMore data for this Ligand-Target Pair
Affinity DataIC50: 3.95E+3nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.01E+3nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.73E+3nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 5.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.41E+4nM EC50: 740nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
Affinity DataIC50: 33nM EC50: 149nMpH: 5.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nM EC50: 1.34E+3nMpH: 6.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.60E+4nM EC50: 4.40E+3nMpH: 6.0 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.80nMpH: 5.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataKi: 1.70E+3nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
Affinity DataKi: 3.84E+3nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
Affinity DataKi: 4.64E+3nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair