BDBM19804 (2S)-4-methyl-N-(4-oxooxolan-3-yl)-2-(quinolin-2-ylformamido)pentanamide::3-amidotetrahydrofuran-4-one, 16::CHEMBL62239

SMILES CC(C)C[C@H](NC(=O)c1ccc2ccccc2n1)C(=O)NC1COCC1=O

InChI Key InChIKey=RETZIRPJWJFESI-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 19804   

TargetCathepsin K(Human)
Gsk

LigandPNGBDBM19804(CHEMBL62239 | (2S)-4-methyl-N-(4-oxooxolan-3-yl)-2...)
Affinity DataKi:  44nM ΔG°:  -9.93kcal/molepH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Gsk

LigandPNGBDBM19804(CHEMBL62239 | (2S)-4-methyl-N-(4-oxooxolan-3-yl)-2...)
Affinity DataKi:  44nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Gsk

LigandPNGBDBM19804(CHEMBL62239 | (2S)-4-methyl-N-(4-oxooxolan-3-yl)-2...)
Affinity DataKi:  250nMAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Gsk

LigandPNGBDBM19804(CHEMBL62239 | (2S)-4-methyl-N-(4-oxooxolan-3-yl)-2...)
Affinity DataKi:  1.10E+3nMAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin B(Human)
Gsk

LigandPNGBDBM19804(CHEMBL62239 | (2S)-4-methyl-N-(4-oxooxolan-3-yl)-2...)
Affinity DataKi:  7.80E+3nM ΔG°:  -6.89kcal/molepH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed