BDBM19798 3-amidotetrahydrofuran-4-one, 3::CHEMBL61805::benzyl N-[(1S)-3-methyl-1-[(4-oxooxolan-3-yl)carbamoyl]butyl]carbamate

SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1COCC1=O

InChI Key InChIKey=GGNPRFIUKYTFLP-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 19798   

TargetCathepsin K(Human)
Gsk

LigandPNGBDBM19798(CHEMBL61805 | benzyl N-[(1S)-3-methyl-1-[(4-oxooxo...)
Affinity DataKi:  140nM ΔG°:  -9.25kcal/molepH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Gsk

LigandPNGBDBM19798(CHEMBL61805 | benzyl N-[(1S)-3-methyl-1-[(4-oxooxo...)
Affinity DataKi:  140nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Gsk

LigandPNGBDBM19798(CHEMBL61805 | benzyl N-[(1S)-3-methyl-1-[(4-oxooxo...)
Affinity DataKi:  310nMAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Gsk

LigandPNGBDBM19798(CHEMBL61805 | benzyl N-[(1S)-3-methyl-1-[(4-oxooxo...)
Affinity DataKi:  2.60E+3nMAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin B(Human)
Gsk

LigandPNGBDBM19798(CHEMBL61805 | benzyl N-[(1S)-3-methyl-1-[(4-oxooxo...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.75kcal/molepH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed