BDBM197953 US9216997, compound 28-8

SMILES CN1C[C@@H]2C[C@H]1CN2CCOc1ccc2c(n1)sc1nc(cn21)-c1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1

InChI Key InChIKey=SSCJBYSRNNRADL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 197953   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Shanghai De Novo Pharmatech

US Patent
LigandPNGBDBM197953(US9216997, compound 28-8)
Affinity DataIC50: 10.9nMAssay Description:FLT3 is a receptor tyrosine kinase involved in survival and proliferation of leukemic cells. Constitutively activating FLT3 mutations has been found ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
Go to US Patent