BDBM19758 benzyl N-[(1S)-1-{[(1R)-2-(tert-butoxy)-1-cyanoethyl]carbamoyl}-3-methylbutyl]carbamate::dipeptidyl nitrile, 5g

SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](COC(C)(C)C)C#N

InChI Key InChIKey=HTRJYWNEPLFXGA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 19758   

TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19758(benzyl N-[(1S)-1-{[(1R)-2-(tert-butoxy)-1-cyanoeth...)
Affinity DataIC50: 240nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19758(benzyl N-[(1S)-1-{[(1R)-2-(tert-butoxy)-1-cyanoeth...)
Affinity DataIC50: 2.80E+3nMpH: 5.5 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19758(benzyl N-[(1S)-1-{[(1R)-2-(tert-butoxy)-1-cyanoeth...)
Affinity DataIC50: 900nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed