BDBM195881 US9670213, Compound 026 N-(3-(2-(4-methoxyphenylamino)-6-methyl-7-oxo-8(7H)-pteridin-yl)phenyl) acrylamide

SMILES COc1ccc(Nc2ncc3nc(C)c(=O)n(-c4cccc(NC(=O)C=C)c4)c3n2)cc1

InChI Key InChIKey=FGPPXNCHKYRZCI-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 195881   

TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195881(US9670213, Compound 026 N-(3-(2-(4-methoxyphenylam...)
Affinity DataIC50: 7.24nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195881(US9670213, Compound 026 N-(3-(2-(4-methoxyphenylam...)
Affinity DataIC50: 5.93nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195881(US9670213, Compound 026 N-(3-(2-(4-methoxyphenylam...)
Affinity DataIC50: 16nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Blk(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195881(US9670213, Compound 026 N-(3-(2-(4-methoxyphenylam...)
Affinity DataIC50: 96nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195881(US9670213, Compound 026 N-(3-(2-(4-methoxyphenylam...)
Affinity DataIC50: 568nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM195881(US9670213, Compound 026 N-(3-(2-(4-methoxyphenylam...)
Affinity DataIC50: 13nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM195881(US9670213, Compound 026 N-(3-(2-(4-methoxyphenylam...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195881(US9670213, Compound 026 N-(3-(2-(4-methoxyphenylam...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of wild type EGFR (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM195881(US9670213, Compound 026 N-(3-(2-(4-methoxyphenylam...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM195881(US9670213, Compound 026 N-(3-(2-(4-methoxyphenylam...)
Affinity DataIC50: 46nMAssay Description:Inhibition of human ITK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195881(US9670213, Compound 026 N-(3-(2-(4-methoxyphenylam...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of GST-tagged human EGFR (668 to 1210 residues) expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed