BDBM19488 2-{2-[2,3-difluoro-4-(2-methylpropyl)phenyl]phenoxy}acetaldehyde::Aldehyde Inhibitor, 12e

SMILES CC(C)Cc1ccc(c(F)c1F)-c1ccccc1OCC=O

InChI Key InChIKey=DKFPXJJEONKADI-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 19488   

TargetCathepsin S(Human)
University of California Berkeley

LigandPNGBDBM19488(2-{2-[2,3-difluoro-4-(2-methylpropyl)phenyl]phenox...)
Affinity DataKi:  9.60nM ΔG°:  -11.4kcal/molepH: 6.1 T: 2°CAssay Description:The proteolytic cleavage of N-acyl aminocoumarins by cathepsins was conducted in Dynatech Microfluor fluorescence 96-well microtiter plates, and read...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetCathepsin K(Human)
University of California Berkeley

LigandPNGBDBM19488(2-{2-[2,3-difluoro-4-(2-methylpropyl)phenyl]phenox...)
Affinity DataKi:  1.24E+3nM ΔG°:  -8.38kcal/molepH: 6.1 T: 2°CAssay Description:The proteolytic cleavage of N-acyl aminocoumarins by cathepsins was conducted in Dynatech Microfluor fluorescence 96-well microtiter plates, and read...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetProcathepsin L(Human)
University of California Berkeley

LigandPNGBDBM19488(2-{2-[2,3-difluoro-4-(2-methylpropyl)phenyl]phenox...)
Affinity DataKi: >1.50E+4nM ΔG°: >-6.84kcal/molepH: 6.1 T: 2°CAssay Description:The proteolytic cleavage of N-acyl aminocoumarins by cathepsins was conducted in Dynatech Microfluor fluorescence 96-well microtiter plates, and read...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetCathepsin B(Human)
University of California Berkeley

LigandPNGBDBM19488(2-{2-[2,3-difluoro-4-(2-methylpropyl)phenyl]phenox...)
Affinity DataKi: >1.50E+4nM ΔG°: >-6.84kcal/molepH: 6.1 T: 2°CAssay Description:The proteolytic cleavage of N-acyl aminocoumarins by cathepsins was conducted in Dynatech Microfluor fluorescence 96-well microtiter plates, and read...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed