BDBM194798 US9206167, 19::USRE48059, Compound of Example 19

SMILES O=C1CCc2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc2N1

InChI Key InChIKey=SVNKBCHDVYMMAY-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 194798   

TargetD(2) dopamine receptor(Rat)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM194798(US9206167, 19 | USRE48059, Compound of Example 19)
Affinity DataKi:  1.20nM ΔG°:  -12.2kcal/molepH: 7.4 T: 2°CAssay Description:The assay was performed according to the method by Kohler et al. (Kohler C, Hall H, Ogren S O and Gawell L, Specific in vitro and in vivo binding of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2A(Rat)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM194798(US9206167, 19 | USRE48059, Compound of Example 19)
Affinity DataKi:  1.20nM ΔG°:  -12.7kcal/molepH: 7.4 T: 2°CAssay Description:The assay was performed according to the method by Leysen J E et al. (Leysen J E, Niemegeers C J E, Van Nueten J M and Laduron P M. [3H] Ketanserin (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Rat)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM194798(US9206167, 19 | USRE48059, Compound of Example 19)
Affinity DataKi:  1.20nMAssay Description:Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Rat)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM194798(US9206167, 19 | USRE48059, Compound of Example 19)
Affinity DataKi:  1.20nMAssay Description:5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent