BDBM194491 BDBM50392245::US9200020, Table 1, Compound 2

SMILES Nc1nc2n(CCNCCP(O)(O)=O)cnc2c(=O)[nH]1

InChI Key InChIKey=QRYGFSNYGOTAKW-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 194491   

TargetHypoxanthine-guanine phosphoribosyltransferase(Human)
The University of Queensland

US Patent
LigandPNGBDBM194491(US9200020, Table 1, Compound 2 | BDBM50392245)
Affinity DataKi:  3.00E+3nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHypoxanthine-guanine phosphoribosyltransferase(Human)
The University of Queensland

US Patent
LigandPNGBDBM194491(US9200020, Table 1, Compound 2 | BDBM50392245)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of human HGPRT using Prib-PP as substrate by spectrophotometric assay in presence of guanineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHypoxanthine phosphoribosyltransferase(Plasmodium vivax)
The University of Queensland

US Patent
LigandPNGBDBM194491(US9200020, Table 1, Compound 2 | BDBM50392245)
Affinity DataKi:  1.10E+4nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
The University of Queensland

US Patent
LigandPNGBDBM194491(US9200020, Table 1, Compound 2 | BDBM50392245)
Affinity DataKi:  1.60E+4nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
In DepthDetails
US Patent