BDBM192753 Hesperadin::US10981896, Compound Hesperadin

SMILES CCS(=O)(=O)Nc1ccc2NC(=O)\C(=C(/Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)c2c1

InChI Key InChIKey=GLDSKRNGVVYJAB-UHFFFAOYSA-N

Data  2 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 192753   

LigandPNGBDBM192753(Hesperadin | US10981896, Compound Hesperadin)
Affinity DataIC50: 780nMpH: 7.5Assay Description:Inhibitors (initial concentration 10 or 60 μM, three-fold serial dilutions) were incubated with IRE1α* in cleavage buffer (20 mM HEPES at p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
University Of Texas

US Patent
LigandPNGBDBM192753(Hesperadin | US10981896, Compound Hesperadin)
Affinity DataIC50: 225nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent