BDBM192501 US10865384, Compound SB203580::US9187470, 104 (SB203580)

SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccncc1)-c1ccc(F)cc1

InChI Key InChIKey=CDMGBJANTYXAIV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 192501   

TargetMitogen-activated protein kinase 13(Human)
Washington University

US Patent
LigandPNGBDBM192501(US9187470, 104 (SB203580) | US10865384, Compound S...)
Affinity DataIC50: 8.76E+7nMT: 2°CAssay Description:The MAPK13 blocking activity of test compounds was determined using an immobilized metal affinity polarization (IMAP) assay containing activated MAPK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2016
Entry Details
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TargetMitogen-activated protein kinase 14(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM192501(US9187470, 104 (SB203580) | US10865384, Compound S...)
Affinity DataIC50: 24nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter p38 MAP kinase binding assay from D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
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TargetCasein kinase I isoform delta(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM192501(US9187470, 104 (SB203580) | US10865384, Compound S...)
Affinity DataIC50: 43nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter p38 MAP kinase binding assay from D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
Go to US Patent

TargetCasein kinase I isoform epsilon(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM192501(US9187470, 104 (SB203580) | US10865384, Compound S...)
Affinity DataIC50: 63nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter p38 MAP kinase binding assay from D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
Go to US Patent

TargetCasein kinase I isoform delta(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM192501(US9187470, 104 (SB203580) | US10865384, Compound S...)
Affinity DataIC50: 43nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
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TargetCasein kinase I isoform epsilon(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM192501(US9187470, 104 (SB203580) | US10865384, Compound S...)
Affinity DataIC50: 63nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
Go to US Patent