BDBM192126 US9187437, 7

SMILES C(CC1(CCCCC1)c1ccccc1)c1nc(no1)-c1ccccc1

InChI Key InChIKey=VQJPAUPNWVQQSG-UHFFFAOYSA-N

Data  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 192126   

TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM192126(US9187437, 7)
Affinity DataIC50: 3.30nMpH: 7.5 T: 2°CAssay Description:Membranes were prepared from CHO cells expressing human S1P1. Cells pellets (1x108 cells/pellet) were suspended in buffer containing 20 mM HEPES, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2016
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM192126(US9187437, 7)
Affinity DataEC50:  130nMT: 2°CAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 ul/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-Ga1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2016
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM192126(US9187437, 7)
Affinity DataEC50:  630nMT: 2°CAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 ul/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-Ga1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2016
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM192126(US9187437, 7)
Affinity DataEC50:  630nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO cell membranes after 45 mins by [35S] GTPgammaS binding based scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2019
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM192126(US9187437, 7)
Affinity DataEC50:  130nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cell membranes after 45 mins by [35S] GTPgammaS binding based scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2019
Entry Details Article
PubMed