BDBM19202 (1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]-1-(thiophen-3-yl)ethan-1-ol::CHEMBL310570::N-Arylpyrazolo[3,2-c]-Based Ligand, 25
SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@](C)(O)c1ccsc1
InChI Key InChIKey=ZYRBSUDYHJGRMJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 19202
Affinity DataIC50: 0.800nM EC50: 1nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human glucocorticoid receptor alpha by displacement of [3H]dexamethasoneMore data for this Ligand-Target Pair
Affinity DataEC50: 36nMAssay Description:Inhibition of GR-mediated tyrosine amino transferase activity in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.960nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 5.20nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
Affinity DataEC50: 8.30nMAssay Description:Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 36nMAssay Description:Transactivation of GAL-4 tagged glucocorticoid receptor ligand binding domain expressed in human HeLa cells assessed as NP1 activation by luciferase ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Binding affinity to androgen receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of PMA-induced AP1 activity after 6 hrs by l...More data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Displacement of GS-red from human glucocorticoid receptor by fluorescent polarization assayMore data for this Ligand-Target Pair