BDBM191767 US11608309, Compound 3::US9187406, Compound 3

SMILES COC(=O)C(C(=O)\C=C\c1ccc(O)cc1)C(=O)\C=C\c1ccc(O)cc1

InChI Key InChIKey=QRIBEDBOVWHYJL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 191767   

TargetMatrix metalloproteinase-9(Human)
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191767(US9187406, Compound 3 | US11608309, Compound 3)
Affinity DataIC50: 6.00E+3nMT: 2°CAssay Description:The synthetic octapeptide substrate, containing the collagenase-susceptible glycine-isoleucine peptide bond, was incubated (37° C.) with commerci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

Target72 kDa type IV collagenase(Human)
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191767(US9187406, Compound 3 | US11608309, Compound 3)
Affinity DataIC50: 7.00E+4nMT: 2°CAssay Description:The synthetic octapeptide substrate, containing the collagenase-susceptible glycine-isoleucine peptide bond, was incubated (37° C.) with commerci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetCollagenase 3(Human)
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191767(US9187406, Compound 3 | US11608309, Compound 3)
Affinity DataIC50: 8.00E+3nMT: 2°CAssay Description:The synthetic octapeptide substrate, containing the collagenase-susceptible glycine-isoleucine peptide bond, was incubated (37° C.) with commerci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetMatrix metalloproteinase-9(Human)
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191767(US9187406, Compound 3 | US11608309, Compound 3)
Affinity DataIC50: 6.00E+3nMAssay Description:Table 1 shows the IC50 of curcumin, compound 1, and compound 2, compared to a standard Zn++ binding & MMPI (matrix metalloproteinase inhibitor), 1,10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

Target72 kDa type IV collagenase(Human)
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191767(US9187406, Compound 3 | US11608309, Compound 3)
Affinity DataIC50: 7.00E+4nMAssay Description:Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetCollagenase 3(Human)
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191767(US9187406, Compound 3 | US11608309, Compound 3)
Affinity DataIC50: 8.00E+3nMAssay Description:Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent