BDBM19136 CHEMBL379049::tert-butyl N-[(1S)-1-(cycloheptylcarbamoyl)-6-sulfanylhexyl]carbamate::thiolate analogue, 18a

SMILES CC(C)(C)OC(=O)N[C@@H](CCCCCS)C(=O)NC1CCCCCC1

InChI Key InChIKey=RTVMPAGMFUPGRI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 19136   

TargetHistone deacetylase 6(Mouse)
Nagoya City University

LigandPNGBDBM19136(tert-butyl N-[(1S)-1-(cycloheptylcarbamoyl)-6-sulf...)
Affinity DataIC50: 23nMpH: 8.0 T: 2°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2007
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Nagoya City University

LigandPNGBDBM19136(tert-butyl N-[(1S)-1-(cycloheptylcarbamoyl)-6-sulf...)
Affinity DataIC50: 900nMpH: 8.0 T: 2°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2007
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Nagoya City University

LigandPNGBDBM19136(tert-butyl N-[(1S)-1-(cycloheptylcarbamoyl)-6-sulf...)
Affinity DataIC50: 840nMAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2007
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Nagoya City University

LigandPNGBDBM19136(tert-butyl N-[(1S)-1-(cycloheptylcarbamoyl)-6-sulf...)
Affinity DataIC50: 900nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Nagoya City University

LigandPNGBDBM19136(tert-butyl N-[(1S)-1-(cycloheptylcarbamoyl)-6-sulf...)
Affinity DataIC50: 840nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM19136(tert-butyl N-[(1S)-1-(cycloheptylcarbamoyl)-6-sulf...)
Affinity DataIC50: 23nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed