BDBM190230 US9175000, 15

SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@]1(CC[C@@]35C[C@@H]1C(NC(C(O)=O)c1ccccc1)c1ccccc1)OC

InChI Key InChIKey=CWRICNOKPCBBSF-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 190230   

TargetMu-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM190230(US9175000, 15)
Affinity DataEC50:  656nMpH: 7.4 T: 2°CAssay Description:[35S]GTPgammaS functional assays were conducted using freshly thawed pt-receptor membranes prepared in-house from a cell line expressing recombinant ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM190230(US9175000, 15)
Affinity DataEC50:  1.77E+3nMpH: 7.4 T: 2°CAssay Description:Membranes from recombinant HEK-293 cells, CHO cells expressing the recombinant human kappa opioid receptor (kappa) were prepared by lysing cells in i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM190230(US9175000, 15)
Affinity DataKi:  51.3nMpH: 7.4Assay Description:Membranes from recombinant HEK-293 cells expressing the human κ opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
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TargetMu-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM190230(US9175000, 15)
Affinity DataKi:  278nM ΔG°:  -9.69kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for mu-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membran...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
Go to US Patent