BDBM189933 US10227346, Example 51::US10426135, Example 51::US9670201, 51 (R)-3-cyano-N-(3-(1-(2-cyclopentylpropanoyl)piperidin-4-yl)-1,4-dimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide::US9920054, Example 51

SMILES C[C@H](C1CCCC1)C(=O)N1CCC(CC1)c1cn(C)c2ncc(NC(=O)c3cccc(c3)C#N)c(C)c12

InChI Key InChIKey=PPVXRQBJXSAFBI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 189933   

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM189933(US9670201, 51 (R)-3-cyano-N-(3-(1-(2-cyclopentylpr...)
Affinity DataIC50: 6.90nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM189933(US9670201, 51 (R)-3-cyano-N-(3-(1-(2-cyclopentylpr...)
Affinity DataIC50: 6.90nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM189933(US9670201, 51 (R)-3-cyano-N-(3-(1-(2-cyclopentylpr...)
Affinity DataIC50: 6.90nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM189933(US9670201, 51 (R)-3-cyano-N-(3-(1-(2-cyclopentylpr...)
Affinity DataIC50: 6.90nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
In DepthDetails
US Patent