BDBM189932 US10227346, Example 50::US10426135, Example 50::US9670201, 50 (R)-N-(3-(1-(2-(bicyclo[1.1.1]pentan-1-yl)propanoyl)piperidin-4-yl)-1,4-dimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-cyanobenzamide::US9920054, Example 50

SMILES C[C@@H](C(=O)N1CCC(CC1)c1cn(C)c2ncc(NC(=O)c3cccc(c3)C#N)c(C)c12)C12CC(C1)C2

InChI Key InChIKey=AHWBBLUUTZIUSU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 189932   

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM189932(US9670201, 50 (R)-N-(3-(1-(2-(bicyclo[1.1.1]pentan...)
Affinity DataIC50: 7.5nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM189932(US9670201, 50 (R)-N-(3-(1-(2-(bicyclo[1.1.1]pentan...)
Affinity DataIC50: 7.5nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM189932(US9670201, 50 (R)-N-(3-(1-(2-(bicyclo[1.1.1]pentan...)
Affinity DataIC50: 7.5nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM189932(US9670201, 50 (R)-N-(3-(1-(2-(bicyclo[1.1.1]pentan...)
Affinity DataIC50: 7.5nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
In DepthDetails
US Patent