BDBM18920 2-[3,5-dichloro-4-(4-hydroxy-3-phenylphenoxy)phenyl]acetic acid::4-hydroxy thyromimetic, 9a

SMILES OC(=O)Cc1cc(Cl)c(Oc2ccc(O)c(c2)-c2ccccc2)c(Cl)c1

InChI Key InChIKey=SQDDKKYHCKRAHR-UHFFFAOYSA-N

Data  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 18920   

TargetThyroid hormone receptor alpha(Human)
Bristol-Myers Squibb

LigandPNGBDBM18920(2-[3,5-dichloro-4-(4-hydroxy-3-phenylphenoxy)pheny...)
Affinity DataIC50: 152nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Bristol-Myers Squibb

LigandPNGBDBM18920(2-[3,5-dichloro-4-(4-hydroxy-3-phenylphenoxy)pheny...)
Affinity DataIC50: 2.90nMAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Bristol-Myers Squibb

LigandPNGBDBM18920(2-[3,5-dichloro-4-(4-hydroxy-3-phenylphenoxy)pheny...)
Affinity DataEC50:  2.90nMAssay Description:Binding affinity to TRbeta1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Bristol-Myers Squibb

LigandPNGBDBM18920(2-[3,5-dichloro-4-(4-hydroxy-3-phenylphenoxy)pheny...)
Affinity DataEC50:  152nMAssay Description:Binding affinity to TRalpha1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Bristol-Myers Squibb

LigandPNGBDBM18920(2-[3,5-dichloro-4-(4-hydroxy-3-phenylphenoxy)pheny...)
Affinity DataIC50: 2.88nMAssay Description:Inhibition of human thyroid hormone receptor beta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Bristol-Myers Squibb

LigandPNGBDBM18920(2-[3,5-dichloro-4-(4-hydroxy-3-phenylphenoxy)pheny...)
Affinity DataIC50: 2.88nMAssay Description:Inhibition of thyroid hormone receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Bristol-Myers Squibb

LigandPNGBDBM18920(2-[3,5-dichloro-4-(4-hydroxy-3-phenylphenoxy)pheny...)
Affinity DataIC50: 129nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed