BDBM18885 2-[4-({4-hydroxy-3-[2-(4-nitrophenyl)ethynyl]-5-(propan-2-yl)phenyl}methyl)-3,5-dimethylphenoxy]acetic acid::CHEMBL109279::JMC496635 Compound 5::thyromimetic, 5b

SMILES CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)cc(C#Cc2ccc(cc2)[N+]([O-])=O)c1O

InChI Key InChIKey=IXMROOKFPWGDGF-UHFFFAOYSA-N

Data  6 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 18885   

TargetThyroid hormone receptor beta(Human)
Karo Bio

LigandPNGBDBM18885(JMC496635 Compound 5 | 2-[4-({4-hydroxy-3-[2-(4-ni...)
Affinity DataIC50: 20nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Karo Bio

LigandPNGBDBM18885(JMC496635 Compound 5 | 2-[4-({4-hydroxy-3-[2-(4-ni...)
Affinity DataIC50: 93nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Karo Bio

LigandPNGBDBM18885(JMC496635 Compound 5 | 2-[4-({4-hydroxy-3-[2-(4-ni...)
Affinity DataIC50: 93nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
Karo Bio

LigandPNGBDBM18885(JMC496635 Compound 5 | 2-[4-({4-hydroxy-3-[2-(4-ni...)
Affinity DataIC50: 20nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
Karo Bio

LigandPNGBDBM18885(JMC496635 Compound 5 | 2-[4-({4-hydroxy-3-[2-(4-ni...)
Affinity DataKd:  20nMAssay Description:Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
Karo Bio

LigandPNGBDBM18885(JMC496635 Compound 5 | 2-[4-({4-hydroxy-3-[2-(4-ni...)
Affinity DataIC50: 370nMAssay Description:Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Karo Bio

LigandPNGBDBM18885(JMC496635 Compound 5 | 2-[4-({4-hydroxy-3-[2-(4-ni...)
Affinity DataIC50: 950nMAssay Description:Half-maximum activation of human Thyroid hormone receptor alpha-1 (hTRalpha1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Karo Bio

LigandPNGBDBM18885(JMC496635 Compound 5 | 2-[4-({4-hydroxy-3-[2-(4-ni...)
Affinity DataKd:  93nMAssay Description:Binding affinity against human Thyroid hormone receptor alpha-1 (hTRalpha1) using radiolabeled T3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed