BDBM187643 US9670193, 35 3-chloro-N-(pyridin-4-ylmethyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)pyridin-2-amine

SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccncc2)c(Cl)c1

InChI Key InChIKey=SYLHXBPKZHFPDJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 187643   

TargetHistone deacetylase 1(Human)
Novartis

US Patent
LigandPNGBDBM187643(US9670193, 35 3-chloro-N-(pyridin-4-ylmethyl)-5-(5...)
Affinity DataIC50: 1.10E+3nMAssay Description:Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
Go to US Patent

TargetHistone deacetylase 4 [2-1084](Human)
Novartis

US Patent
LigandPNGBDBM187643(US9670193, 35 3-chloro-N-(pyridin-4-ylmethyl)-5-(5...)
Affinity DataIC50: 11nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Novartis

US Patent
LigandPNGBDBM187643(US9670193, 35 3-chloro-N-(pyridin-4-ylmethyl)-5-(5...)
Affinity DataIC50: 1.80E+3nMAssay Description:Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
Go to US Patent