BDBM18685 (2R)-3-{[4-(2-chloroacetamido)phenyl]sulfanyl}-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide::Bicalutamide Analogue, (R)-11::CHEMBL333745

SMILES C[C@](O)(CSc1ccc(NC(=O)CCl)cc1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=HHSHETLZYRKYOK-UHFFFAOYSA-N

Data  4 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 18685   

TargetAndrogen receptor(Rat)
University of Tennessee At Memphis

LigandPNGBDBM18685(CHEMBL333745 | (2R)-3-{[4-(2-chloroacetamido)pheny...)
Affinity DataKi:  1.65nM ΔG°:  -11.1kcal/molepH: 7.4 T: 2°CAssay Description:The Ki values were determined by the application of the Cheng-Prusoff equation: Ki = (IC50 x Kd)/(Kd+[L]) where [L] is the concentration of [3H]MIB (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Rat)
University of Tennessee At Memphis

LigandPNGBDBM18685(CHEMBL333745 | (2R)-3-{[4-(2-chloroacetamido)pheny...)
Affinity DataKi:  1.65nM ΔG°:  -11.1kcal/mole EC50:  100nMpH: 7.4 T: 2°CAssay Description:The Ki values were determined by the application of the Cheng-Prusoff equation: Ki = (IC50 x Kd)/(Kd+[L]) where [L] is the concentration of [3H]MIB (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Gtx

Curated by ChEMBL
LigandPNGBDBM18685(CHEMBL333745 | (2R)-3-{[4-(2-chloroacetamido)pheny...)
Affinity DataKi:  1.65nMAssay Description:Agonist activity at androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Rat)
University of Tennessee At Memphis

LigandPNGBDBM18685(CHEMBL333745 | (2R)-3-{[4-(2-chloroacetamido)pheny...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of [3H]mibolerone binding to cytosolic androgen receptor of rat ventral prostateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed