BDBM185918 US9163008, 7::US9656968, Compound 7

SMILES NC(=O)c1cc(N[C@H]2CCNC2=O)nc(n1)-c1ccc(Oc2ccc(F)cc2)cc1

InChI Key InChIKey=CCBSICWZDFRVAU-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 185918   

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM185918(US9163008, 7 | US9656968, Compound 7)
Affinity DataIC50: 170nMAssay Description:In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2016
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM185918(US9163008, 7 | US9656968, Compound 7)
Affinity DataIC50: 170nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM185918(US9163008, 7 | US9656968, Compound 7)
Affinity DataKi:  53nMpH: 7.4Assay Description:For electrophysiological recordings the external solution was either standard, DMEM supplemented with 10 mM HEPES (pH adjusted to 7.34 with NaOH and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2016
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM185918(US9163008, 7 | US9656968, Compound 7)
Affinity DataKi:  53nMAssay Description:Cells: The hNav1.7 expressing HEK-293 cells were plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DMEM culture media (Mediate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
Go to US Patent