BDBM185588 US9156852, 59::USRE47451, Example 59

SMILES CN(C)Cc1cc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)ccc1Cl

InChI Key InChIKey=SLCWKPNWOMBQAA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 185588   

TargetSerine/threonine-protein kinase B-raf(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185588(US9156852, 59 | USRE47451, Example 59)
Affinity DataIC50: 42nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185588(US9156852, 59 | USRE47451, Example 59)
Affinity DataIC50: 7nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185588(US9156852, 59 | USRE47451, Example 59)
Affinity DataIC50: 6nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase B-raf [409-765](Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185588(US9156852, 59 | USRE47451, Example 59)
Affinity DataIC50: 42nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185588(US9156852, 59 | USRE47451, Example 59)
Affinity DataIC50: 7nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM185588(US9156852, 59 | USRE47451, Example 59)
Affinity DataIC50: 6nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails
US Patent