BDBM185384 US9156845, 28

SMILES CN1CCC2(CC1)CN(CCO2)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

InChI Key InChIKey=HEZSSKBBLQBTMF-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 185384   

LigandPNGBDBM185384(US9156845, 28)
Affinity DataIC50: 40nMpH: 7.5Assay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2016
Entry Details
Go to US Patent

LigandPNGBDBM185384(US9156845, 28)
Affinity DataIC50: 201nMpH: 7.5Assay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2016
Entry Details
Go to US Patent

LigandPNGBDBM185384(US9156845, 28)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation pretreated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProtein kinase C eta type(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM185384(US9156845, 28)
Affinity DataKi:  2.40nMAssay Description:Inhibition of full length human recombinant PKCeta expessed in baculovirus infected insect cells using 5-FAM-RFARKGSLRQKNV-COOH peptide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM185384(US9156845, 28)
Affinity DataKi:  17nMAssay Description:Inhibition of full length human recombinant HPK1 expressed in baculovirus-infected insect cells using 5-FAM-KRRALSSLRA-COOH peptide as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProtein kinase C theta type(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM185384(US9156845, 28)
Affinity DataKi:  22nMAssay Description:Inhibition of full length C-terminal his6-tagged human recombinant PKCtheta using -FAMRFARKGSLRQKNV-COOH peptide as substrate preincubated with enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed