BDBM18511 6-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxyphenyl}hexanoic acid::CHEMBL33921::Diaminopyrimidine, 23

SMILES COc1ccc(CCCCCC(O)=O)cc1Cc1cnc(N)nc1N

InChI Key InChIKey=LJRZTUYWOPFKKK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 18511   

TargetDihydrofolate reductase(Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG...)
University of Connecticut At Storrs

LigandPNGBDBM18511(CHEMBL33921 | 6-{3-[(2,4-diaminopyrimidin-5-yl)met...)
Affinity DataIC50: 1.50E+5nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18511(CHEMBL33921 | 6-{3-[(2,4-diaminopyrimidin-5-yl)met...)
Affinity DataIC50: 8.40nMAssay Description:Inhibitory activity against Dihydrohydrofolate reductase(DHFR) of Toxoplasma gondiiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18511(CHEMBL33921 | 6-{3-[(2,4-diaminopyrimidin-5-yl)met...)
Affinity DataIC50: 150nMAssay Description:Inhibition of Dihydrohydrofolate reductase(DHFR) of Pneumocystis cariniiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18511(CHEMBL33921 | 6-{3-[(2,4-diaminopyrimidin-5-yl)met...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition Dihydrohydrofolate reductase(DHFR) of rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18511(CHEMBL33921 | 6-{3-[(2,4-diaminopyrimidin-5-yl)met...)
Affinity DataIC50: 16nMAssay Description:Inhibition of Dihydrohydrofolate reductase(DHFR) of Mycobacterium aviumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed