BDBM184557 US9150579, B2

SMILES CC(C)Oc1ccc(cc1F)-c1nn([C@H](C)c2oc3ccc(F)cc3c(=O)c2-c2cccc(F)c2)c2ncnc(N)c12

InChI Key InChIKey=IUVCFHHAEHNCFT-UHFFFAOYSA-N

Data  1 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 184557   

LigandPNGBDBM184557(US9150579, B2)
Affinity DataIC50: 1.45E+3nMT: 2°CAssay Description:The homogenous time resolved fluorescence (HTRF) assay allows detection of 3,4,5-triphosphate (PIP3) formed as a result of phosphorylation of phospho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
Go to US Patent

LigandPNGBDBM184557(US9150579, B2)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PI3Kalpha (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM184557(US9150579, B2)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PI3Kbeta (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM184557(US9150579, B2)
Affinity DataKd: >1.40E+3nMAssay Description:Binding affinity to PI3Kgamma (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM184557(US9150579, B2)
Affinity DataKd: >6.20nMAssay Description:Binding affinity to PI3Kdelta (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed