BDBM18376 (3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoic acid::Cerivastatin::cid_446156

SMILES COCc1c(nc(C(C)C)c(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)c1-c1ccc(F)cc1)C(C)C

InChI Key InChIKey=SEERZIQQUAZTOL-UHFFFAOYSA-N

Data  2 KI  4 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 18376   

LigandPNGBDBM18376((3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)...)
Affinity DataIC50: 2.80nM EC50:  1.70nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
LigandPNGBDBM18376((3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)...)
Affinity DataIC50: 2.80nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
LigandPNGBDBM18376((3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)...)
Affinity DataIC50: 9.80nM EC50:  2.30nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Southern Research Institute

Curated by PubChem BioAssay
LigandPNGBDBM18376((3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)...)
Affinity DataEC50: >5.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details
PCBioAssay
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM18376((3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against 3-hydroxy-3-methylglutaryl-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetBile salt export pump(Human)
University of Tokyo

Curated by PDSP Ki Database
LigandPNGBDBM18376((3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2012
Entry Details Article
PubMed
TargetBile salt export pump(Rat)
University of Tokyo

Curated by PDSP Ki Database
LigandPNGBDBM18376((3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2012
Entry Details Article
PubMed