BDBM18239 2,4-diamino-5-deazapteridine, 8::Piritrexim analogue,31::ethyl 5-[3-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl}methyl)-4-methoxyphenoxy]pentanoate

SMILES CCOC(=O)CCCCOc1ccc(OC)c(Cc2cnc3nc(N)nc(N)c3c2C)c1

InChI Key InChIKey=MXQNQGPRVZDOOS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 18239   

TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

LigandPNGBDBM18239(ethyl 5-[3-({2,4-diamino-5-methylpyrido[2,3-d]pyri...)
Affinity DataIC50: 28nMpH: 7.4 T: 2°CAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

LigandPNGBDBM18239(ethyl 5-[3-({2,4-diamino-5-methylpyrido[2,3-d]pyri...)
Affinity DataIC50: 11nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

LigandPNGBDBM18239(ethyl 5-[3-({2,4-diamino-5-methylpyrido[2,3-d]pyri...)
Affinity DataIC50: 9.40nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

LigandPNGBDBM18239(ethyl 5-[3-({2,4-diamino-5-methylpyrido[2,3-d]pyri...)
Affinity DataIC50: 14nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG...)
University of Connecticut At Storrs

LigandPNGBDBM18239(ethyl 5-[3-({2,4-diamino-5-methylpyrido[2,3-d]pyri...)
Affinity DataIC50: 350nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed