BDBM181027 US9133183, Example 90

SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)N3CCN(C3=O)C(C)(C)C)nc2)ccn1

InChI Key InChIKey=RUOYMBZKKMTSLG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 181027   

TargetMacrophage colony-stimulating factor 1 receptor [538-972](Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM181027(US9133183, Example 90)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHepatocyte growth factor receptor(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM181027(US9133183, Example 90)
Affinity DataIC50: 5.00E+3nMT: 2°CAssay Description:These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM181027(US9133183, Example 90)
Affinity DataIC50: 3.30E+3nMT: 2°CAssay Description:These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...More data for this Ligand-Target Pair
In DepthDetails
US Patent