BDBM17666 2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)methyl]-1H-1,3-benzodiazole::CHEMBL58581::benzimidazole analogue, 2

SMILES Fc1cccc(F)c1Cn1c(nc2ccccc12)-c1c(F)cccc1F

InChI Key InChIKey=MDIRLWZOKMHIJZ-UHFFFAOYSA-N

Data  2 IC50  14 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 17666   

TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
Nci-Fcrdc

LigandPNGBDBM17666(CHEMBL58581 | 2-(2,6-difluorophenyl)-1-[(2,6-diflu...)
Affinity DataIC50: 110nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2007
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17666(CHEMBL58581 | 2-(2,6-difluorophenyl)-1-[(2,6-diflu...)
Affinity DataEC50:  1.29E+4nMAssay Description:Cross Resistance (antiviral activity) with K103N (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17666(CHEMBL58581 | 2-(2,6-difluorophenyl)-1-[(2,6-diflu...)
Affinity DataEC50:  460nMAssay Description:Cross Resistance (antiviral activity) with L74V (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17666(CHEMBL58581 | 2-(2,6-difluorophenyl)-1-[(2,6-diflu...)
Affinity DataEC50: >2.00E+4nMAssay Description:Cross Resistance (antiviral activity) with V106A (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17666(CHEMBL58581 | 2-(2,6-difluorophenyl)-1-[(2,6-diflu...)
Affinity DataIC50: 1.10E+5nMAssay Description:The quantity of compound required to reduce WT Reverse transcriptase activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17666(CHEMBL58581 | 2-(2,6-difluorophenyl)-1-[(2,6-diflu...)
Affinity DataEC50:  1.85E+3nMAssay Description:Cross Resistance (antiviral activity) with NL4-3(WT) NNRTI (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17666(CHEMBL58581 | 2-(2,6-difluorophenyl)-1-[(2,6-diflu...)
Affinity DataEC50:  1.04E+4nMAssay Description:Cross Resistance (antiviral activity) with V108I (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17666(CHEMBL58581 | 2-(2,6-difluorophenyl)-1-[(2,6-diflu...)
Affinity DataEC50:  1.52E+4nMAssay Description:Cross Resistance (antiviral activity) with Y181C (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17666(CHEMBL58581 | 2-(2,6-difluorophenyl)-1-[(2,6-diflu...)
Affinity DataEC50:  2.30E+3nMAssay Description:Cross Resistance (antiviral activity) with V179D (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17666(CHEMBL58581 | 2-(2,6-difluorophenyl)-1-[(2,6-diflu...)
Affinity DataEC50:  1.17E+4nMAssay Description:Cross Resistance (antiviral activity) with Y188C (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17666(CHEMBL58581 | 2-(2,6-difluorophenyl)-1-[(2,6-diflu...)
Affinity DataEC50:  840nMAssay Description:Cross Resistance (antiviral activity) with 4xAZT/L100I (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17666(CHEMBL58581 | 2-(2,6-difluorophenyl)-1-[(2,6-diflu...)
Affinity DataEC50:  270nMAssay Description:Cross Resistance (antiviral activity) with 4xAZT (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17666(CHEMBL58581 | 2-(2,6-difluorophenyl)-1-[(2,6-diflu...)
Affinity DataEC50:  4.75E+3nMAssay Description:Cross Resistance (antiviral activity) with A98G (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17666(CHEMBL58581 | 2-(2,6-difluorophenyl)-1-[(2,6-diflu...)
Affinity DataEC50: >2.00E+4nMAssay Description:Cross Resistance (antiviral activity) with K101E (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17666(CHEMBL58581 | 2-(2,6-difluorophenyl)-1-[(2,6-diflu...)
Affinity DataEC50: >2.00E+4nMAssay Description:Cross Resistance (antiviral activity) with 4xAZT/Y181C (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17666(CHEMBL58581 | 2-(2,6-difluorophenyl)-1-[(2,6-diflu...)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of HIV-1 reverse transcriptase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed