BDBM174963 US9096593, P-2165

SMILES COc1ncc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)c(F)n2)cc1F

InChI Key InChIKey=ZYUJERAVFWUVMN-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 174963   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Plexxikon

US Patent
LigandPNGBDBM174963(US9096593, P-2165)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:In one assay the biochemical activity IC50 values are determined with respect to inhibition of Fms kinase activity, where inhibition of phosphorylati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
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TargetMast/stem cell growth factor receptor Kit(Human)
Plexxikon

US Patent
LigandPNGBDBM174963(US9096593, P-2165)
Affinity DataIC50: 100nMpH: 7.5Assay Description:In one assay the biochemical activity IC50 values are determined with respect to inhibition of c-Kit kinase activity, where inhibition of phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Plexxikon

US Patent
LigandPNGBDBM174963(US9096593, P-2165)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:In one assay the biochemical activity IC50 values are determined with respect to inhibition of Flt-3 kinase activity, where inhibition of phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
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TargetCytochrome P450 1A2(Human)
Plexxikon

US Patent
LigandPNGBDBM174963(US9096593, P-2165)
Affinity DataIC50: 1.00E+4nMAssay Description:CYP (Cytochrome P450) enzymes are the major drug metabolizing enzymes present in the liver. The inhibition of CYP enzyme activity (IC50) for each of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
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TargetCytochrome P450 2C19(Human)
Plexxikon

US Patent
LigandPNGBDBM174963(US9096593, P-2165)
Affinity DataIC50: 1.00E+4nMAssay Description:CYP (Cytochrome P450) enzymes are the major drug metabolizing enzymes present in the liver. The inhibition of CYP enzyme activity (IC50) for each of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
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TargetCytochrome P450 2C9(Human)
Plexxikon

US Patent
LigandPNGBDBM174963(US9096593, P-2165)
Affinity DataIC50: 1.00E+4nMAssay Description:CYP (Cytochrome P450) enzymes are the major drug metabolizing enzymes present in the liver. The inhibition of CYP enzyme activity (IC50) for each of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
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TargetCytochrome P450 2D6(Human)
Plexxikon

US Patent
LigandPNGBDBM174963(US9096593, P-2165)
Affinity DataIC50: 1.00E+4nMAssay Description:CYP (Cytochrome P450) enzymes are the major drug metabolizing enzymes present in the liver. The inhibition of CYP enzyme activity (IC50) for each of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Plexxikon

US Patent
LigandPNGBDBM174963(US9096593, P-2165)
Affinity DataIC50: 1.00E+4nMAssay Description:CYP (Cytochrome P450) enzymes are the major drug metabolizing enzymes present in the liver. The inhibition of CYP enzyme activity (IC50) for each of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Plexxikon

US Patent
LigandPNGBDBM174963(US9096593, P-2165)
Affinity DataIC50: 1.00E+4nMAssay Description:CYP (Cytochrome P450) enzymes are the major drug metabolizing enzymes present in the liver. The inhibition of CYP enzyme activity (IC50) for each of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
Go to US Patent