BDBM1747 2-Amino-6-arylthiobenzonitrile deriv. 1q::2-amino-6-{[3-(trifluoromethyl)phenyl]sulfanyl}benzonitrile

SMILES Nc1cccc(Sc2cccc(c2)C(F)(F)F)c1C#N

InChI Key InChIKey=UUJOBWGNKWEIMI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 1747   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1747(2-amino-6-{[3-(trifluoromethyl)phenyl]sulfanyl}ben...)
Affinity DataIC50: 7.10E+3nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2004
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM1747(2-amino-6-{[3-(trifluoromethyl)phenyl]sulfanyl}ben...)
Affinity DataIC50: 7.08E+3nMAssay Description:Inhibitory concentration against Reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM1747(2-amino-6-{[3-(trifluoromethyl)phenyl]sulfanyl}ben...)
Affinity DataIC50: 7.10E+6nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM1747(2-amino-6-{[3-(trifluoromethyl)phenyl]sulfanyl}ben...)
Affinity DataIC50: 7.08E+3nMAssay Description:Inhibition of HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article