BDBM17448 1,2,3-triazole analogue, 4::5-phenyl-1H-1,2,3-triazole

SMILES c1[nH]nnc1-c1ccccc1

InChI Key InChIKey=LUEYUHCBBXWTQT-UHFFFAOYSA-N

Data  2 KI  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 17448   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM17448(5-phenyl-1H-1,2,3-triazole | 1,2,3-triazole analog...)
Affinity DataIC50: 1.43E+5nMAssay Description:Inhibition of human recombinant indoleamine-2,3-dioxygenase expressed in Escherichia coli BL21 using L-tryptophan as substrate after 30 mins by micro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM17448(5-phenyl-1H-1,2,3-triazole | 1,2,3-triazole analog...)
Affinity DataIC50: 2.51E+5nMAssay Description:Inhibition of indoleamine-2,3-dioxygenase in human HEK293 cells assessed as N-formylkynurenine level after 5 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Mouse)
Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM17448(5-phenyl-1H-1,2,3-triazole | 1,2,3-triazole analog...)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of mouse recombinant TDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM17448(5-phenyl-1H-1,2,3-triazole | 1,2,3-triazole analog...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human recombinant IDO expressed in Escherichia coli BL21 AIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Mouse)
Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM17448(5-phenyl-1H-1,2,3-triazole | 1,2,3-triazole analog...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of mouse recombinant IDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM17448(5-phenyl-1H-1,2,3-triazole | 1,2,3-triazole analog...)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of human recombinant IDO expressed in HEK293 cells assessed as blockade of tryptophan degradation by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM17448(5-phenyl-1H-1,2,3-triazole | 1,2,3-triazole analog...)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of human IDO1 transfected in mouse P815B clone-6 cells by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Mouse)
Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM17448(5-phenyl-1H-1,2,3-triazole | 1,2,3-triazole analog...)
Affinity DataIC50: 180nMAssay Description:Inhibition of mouse IDO1 in P815 clone 6 cells by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Mouse)
Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM17448(5-phenyl-1H-1,2,3-triazole | 1,2,3-triazole analog...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Ludwig Center For Cancer Research of The University of Lausanne

Curated by ChEMBL
LigandPNGBDBM17448(5-phenyl-1H-1,2,3-triazole | 1,2,3-triazole analog...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human TDO transfected in mouse P815B clone 19 cells by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM17448(5-phenyl-1H-1,2,3-triazole | 1,2,3-triazole analog...)
Affinity DataIC50: 8.30E+4nMpH: 6.5Assay Description:Inhibition of human recombinant N-terminal His-tagged IDO1 (Ala2 to Gly403) overexpressed in Escherichia coli BL21 at pH 6.5 after 60 mins by HPLC an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM17448(5-phenyl-1H-1,2,3-triazole | 1,2,3-triazole analog...)
Affinity DataKi:  70nM ΔG°:  -9.66kcal/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM17448(5-phenyl-1H-1,2,3-triazole | 1,2,3-triazole analog...)
Affinity DataKi:  2.25E+4nMAssay Description:Uncompetitive inhibition of human recombinant indoleamine-2,3-dioxygenase expressed in Escherichia coli BL21 using L-tryptophan as substrate by Dixon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed