BDBM174025 US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)-1H-pyrrole-2-carboxamide (compd 246)

SMILES NC(=O)C1=CN(CN1c1cc(ccc1Cl)C(F)(F)F)c1ncnc2C=NCc12

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 174025   

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174025(US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-...)
Affinity DataIC50: 212nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174025(US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-...)
Affinity DataIC50: 18nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174025(US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-...)
Affinity DataIC50: 58nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
In DepthDetails
US Patent